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. 2018 Jun 16;38(8):715–726. doi: 10.1007/s40261-018-0658-9

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Dose proportionality of fentanyl a C_maxn, b AUC_0–inf, and c AUC_0–t after administration of fentanyl sublingual spray 100 µg (Cycle 1), 200 µg (Cycle 2), and 400 µg (Cycle 3) every 4 h (Cohort 1), 2 h (Cohort 2), 1 h (Cohort 3), or 0.5 h (Cohort 4). AUC_0–t area under the plasma concentration–time curve from time–zero to the time of the last quantifiable concentration, calculated using the linear-log trapezoidal rule, AUC_0–inf area under the plasma concentration–time curve from time–zero extrapolated to infinity, calculated using the linear-log trapezoidal rule, C_maxn maximum plasma concentrations after last dose