Duplicates removed	21
Excluded at initial screening (e.g. press releases; news reports; not relevant drug/indication)	8
Excluded during initial selection (e.g. preclinical study; reviews; case reports; not randomized trial)	6
Excluded during writing (e.g. reviews; duplicate data; small patient number; nonrandomized/phase I/II trials)	20
Cited efficacy/tolerability articles	9
Cited articles not efficacy/tolerability	22
Search Strategy: EMBASE, MEDLINE and PubMed from 1946 to present. Clinical trial registries/databases and websites were also searched for relevant data. Key words were R Nonacog beta pegol, Refixia, N9-GP, haemophilia B, hemophilia B, factor IX, FIX, deficient, deficiency. Records were limited to those in English language. Searches last updated 27 October 2017