Fig. 2. Normal urinary bladder urothelium (2A) compared to simple urothelial hyperplasia (2B), the initial abnormality to be evaluated in the proposed screening procedure. More severe hyperplasia (nodular and/or papillary hyperplasia) can be detected in this short term screen if the toxicity is sufficient to damage the full thickness of the epithelium (ulceration), usually accompanied by inflammation (original magnification ×200).
