Fig. 4.

Scatterplots showing the relationships between the binding (BP_ND) of the tau tracers (¹¹C-ΤΗΚ5351 and ¹¹C-PBB3) and the decline in FSIQ (global cognition; a, b), ROCF delayed recall (episodic memory; c, d) and MMSE (global cognition; e, f). The declines in FSIQ and ROCF delayed recall are expressed as z-scores from comparison with a reference group of healthy controls [21]. The results presented were derived from data without correction for the partial volume effect. Open circles patients with prodromal Alzheimer’s disease, closed circles patients with Alzheimer’s disease dementia (rho Spearman’s rho). *p < 0.05