. 2018 Jul 11;35(9):176. doi: 10.1007/s11095-018-2454-x

Table I.

Examples of 3D Printed Medicines Prepared with Different 3D Printing Methods

Manufacturing method	Dosage form	API	Excipients	Effect	Ref.
Powder solidifcation
Drop on solid	Implant	Isoniazide	Powder: PLLA Ink: Acethone, Ethanole, Water	Sustained release	(5)
Drop on solid	Tablets	Captopril	Powders: maltitol, maltodextrin, Ink: Water Polyvinylpyrrolidone	Rapidly dispersing tablets	(6)
Selective laser sintering	Orodispersible tablets	Paracetamol	hydroxypropyl methylcellulose vinylpyrrolidone-vinyl acetate copolymer	Orodispersible tablets, fast drug release	(7)
Liquid solidification
Stereolithography	Tablets	Paracetamol 4-Aminosalicylic acid	Poly(ethylene glycol) diacrylate, Poly(ethylene glycol) 300, diphenyl(2,4,6- trimethylbenzoyl) phosphine oxide	Controlled release	(8)
Stereolithography	Microneedles	Insulin	Dental SG resin Xylitol, Mannitol, Trehalose	Insulin skin delivery	(9)
Drop on drop	Tablets	Ropinirole HCl	Irgacure 2959 Poly(ethylene glycol) diacrylate	Fickian diffusion API release mechanizm	(10)
Drop on drop	Tablets	Fenofibrate	White beeswax	Fickian diffusion API release mechanizm	(11)
Extrusion based methods
Fused deposition modelling	Orodispersible films	Aripiprazole	Polyvinyl alcohol	Fast disintegration and dissolution	(12)
Fused deposition modelling	Tablets	Theophylline	Hydroxypropyl cellulose, Triacetin, Sodium starch glycolate, Croscarmellose sodium, Crospovidone,	Immediate release	(13)
Extrusion at room temperature	Floating tablets	Dipyridamole	Hydroxypropyl methyl cellulose, Microcrystalline cellulose, Lactose, Polyvinyl pyrrolidone	Sustained release, gastrofloating dosage form	(14)
Extrusion at room temperature	Multi-compartment tablet	Nifedypine, Captopril, Glipizide	Polyethylene glycol 6000, Microcrystalline cellulose, Hydroxypropyl methylcelloluse, D-Mannitol, Lactose, Sodium starch glycolate, Croscarmellose sodium, Sodium chloride, Tromethamine	Controlled release	(15)