Table 3.
Comparison of clinical findings of CEAS patients by sex
| Male (n = 13) |
Female (n = 33) |
p* | |
|---|---|---|---|
| Age at diagnosis (years, median) | 31 | 40.5 | NS |
| Age at onset (years, median) | 14 | 19 | NS |
| Consanguinity | 3 (23%) | 10 (30%) | NS |
| Family history | 3 (23%) | 7 (21%) | NS |
| Past history of NSAIDs use† | 1/13 (7.7%) | 1/31 (3.2%) | NS |
| History of H. pylori infection‡ | 1/11 (9.1%) | 4/10 (40%) | NS |
| Symptoms | |||
| Abdominal pain | 4 (31%) | 14 (42%) | NS |
| Disease site | |||
| Stomach | 0 | 12 (36%) | 0.01 |
| Duodenum | 8 (62%) | 14 (42%) | NS |
| Jejunum§ | 5 (42%) | 9 (27%) | NS |
| Ileum§ (except for terminal ileum) | 11 (92%) | 33 (100%) | NS |
| Laboratory data at diagnosis | |||
| Hemoglobin (g/dl, median) | 10.2 (2.3–13.5) | 9.5 (4.8–13.7) | NS |
| Serum protein (g/dl, median) | 5.5 (4.8–8.2) | 5.0 (2.7–6.7) | 0.009 |
| CRP (g/dl, median) | 0.26 (0–1.6) | 0.20 (0–1.1) | NS |
| Surgery | 6 (46%) | 23 (70%) | NS |
| c.940 + 1G > A homozygous mutation | 7 (54%) | 10 (30%) | NS |
| Extra-intestinal manifestations | |||
| Digital clubbing | 7 (54%) | 3 (9.1%) | 0.003 |
| Periostosis| | 7 (54%) | 4 (13%) | 0.008 |
| Arthralgia of large joints | 2 (15%) | 5 (15%) | NS |
| Pachydermia | 8 (62%) | 0 | < 0.0001 |
NS not significant
Significant p values are indicated in bold
* Fisher’s exact test or Mann–Whitney U test
Data are available for †44, ‡21 and §45 patients, respectively
|Data are available for 44 patients with X-ray evaluation