Table 4.
Comparison of clinical findings of CEAS patients by c.940 + 1G > A mutation
| c.940 + 1G > A homozygotes group (n = 17) | Non-c.940 + 1G > A homozygotes group (n = 29) | p* | |
|---|---|---|---|
| Age at diagnosis (years, median) | 38 | 42.5 | NS |
| Age at onset (years, median) | 14 | 19 | NS |
| Symptoms | |||
| Abdominal pain | 8 (47%) | 10 (34%) | NS |
| Disease site | |||
| Stomach | 4 (24%) | 8 (28%) | NS |
| Duodenum | 11 (65%) | 11 (38%) | NS |
| Jejunum† | 3 (18%) | 11 (39%) | NS |
| Ileum† (except for terminal ileum) | 16 (94%) | 28 (100%) | NS |
| Laboratory data at diagnosis | |||
| Hemoglobin (g/dl, median) | 10.7 (4.8–13.5) | 9.4 (2.3–13.7) | NS |
| Serum protein (g/dl, median) | 5.4 (1.2–8.2) | 5.0 (2.7–7.0) | 0.03 |
| CRP (g/dl, median) | 0.20 (0–1.6) | 0.20 (0–1.1) | NS |
| Surgery | 11 (65%) | 18 (62%) | NS |
| Extra-intestinal manifestations | |||
| Digital clubbing | 3 (18%) | 7 (24%) | NS |
| Periostosis | 4 (24%) | 7 (26%) | NS |
| Arthralgia of large joints | 4 (24%) | 3 (10%) | NS |
| Pachydermia | 4 (24%) | 4 (14%) | NS |
NS not significant
A significant p value is indicated in bold
* Fisher’s exact test or Mann–Whitney U test
†Data are available for 45 patients