Table 1.

Comparison of current diagnostic criteria for transplant-associated thrombotic microangiopathy (TA-TMA). NB: for Jodele’s criteria, if 1, 2, 3 are present, consider a diagnosis of TA-TMA and monitor very closely. Otherwise, 2 and 4 indicate features associated with poor outcome; therefore, consider therapeutic intervention [6, 12, 17, 18]

	Leukaemia Net International Working Group [17]	Blood and Marrow Transplant Clinical Trials Network [12]	Probably TMA [18]	Jodele’s proposed criteria [6]
Platelet count	<50,000/mm3 or <50% of baseline	N/A	<50,000/mm3 or <50% of baseline	<50,000/mm3 or <50% of baseline
Schistocytes	>4%	>2 per high power field	Present in peripheral blood or microangiopathy on tissue specimen	Present in peripheral blood or microangiopathy on tissue specimen
LDH	Increased	Increased	Increased	Increased
Haptoglobin	Decreased	N/A	De novo anaemia with haptoglobin below lower limit of normal	N/A
Transfusions	Increased	N/A	Anaemia requiring transfusion support	Hb below lower limit of normal for age or transfusion support
Direct Coombs test	N/A	Negative	Negative	N/A
Creatinine	N/A	2 x baseline	N/A	N/A
Coagulation studies	Normal	Normal	Normal	N/A
Terminal complement				Elevated plasma concentration of sC5b-9
Proteinuria	N/A	N/A	N/A	Random urinalysis proteinuria concentration of ≥30 mg/dL
Hypertension	N/A	N/A	N/A	3–18 years: BP at 95th percentile value for age, sex and height; > 18 years: BP ≥140/90 mmHg

LDH lactate dehydrogenase, Hb haemoglobin, BP blood pressure