Table 2.

Factors that increase the risk of kidney injury in children receiving cisplatin

Risk factors for cisplatin-induced kidney injury	References
Increasing cumulative dose	[35]
Shorter administration time	[35]
Concurrent treatment with other nephrotoxins (e.g. ifosfamide/loop diuretics/aminoglycosides)	[36]
Increased peak serum/urine platinum concentrations (interindividual differences in pharmacokinetics)	[35, 39]
Increasing patient age	[41]