Table 1.
Microarray Values for Differentially Expressed Genes Involved in Fertility or Spermatogenesis in TCDD-lineage F0–F2 Testes
| Symbol | Name | F0 |
F1 |
F2 |
|||
|---|---|---|---|---|---|---|---|
| FC | p-value | FC | p-value | FC | p-value | ||
| acox1 | Acyl-coenzyme A oxidase 1 | −1.32 | >0.1 | 10.65 | 0.0071 | 6.12 | 0.000522 |
| gcga | Glucagon a | 1.3 | >0.1 | 7.96 | 0.034 | 3.14 | >0.1 |
| ins | Preproinsulin | 1.17 | >0.1 | 3.86 | 0.038 | 3.06 | 0.099364 |
| sgk1 | Serum/glucocorticoid regulated kinase 1 | 1.32 | 0.03904 | 2.22 | 0.039 | −1.17 | >0.1 |
| gcgb | Glucagon b | −1.09 | >0.1 | 2.08 | 0.03 | 2.52 | >0.1 |
| spata4 | Spermatogenesis associated 4 | −1.77 | 0.073348 | −19.12 | 0.050589 | 8.22 | 0.000078 |
| nudt15 | Nudix (nucleoside diphosphate linked moiety X)-type motif 15 | −3.03 | 0.0086 | −2.48 | 0.094414 | 3.68 | 0.002318 |
| hsp70 | Heat shock protein 70 | −1.49 | 0.022 | −1.21 | >0.1 | 1.98 | 0.002 |
| ftr50 | finTRIM( tripartite motif) family, member 50 | 1.14 | >0.1 | −18.24 | >0.1 | −131.88 | 0.038 |
Fold changes and p-values for microarray data are listed per gene; p-value is determined using ANOVA. Bolded text indicates significant difference from control (FC >1.5, p-value <0.05).
TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; FC, fold change; ANOVA, analysis of variance.