Table 3.

The effects of chronic caffeine administration and antidepressant drug (agomelatine, mianserin) treatment simultaneously with caffeine on the concentrations of caffeine in mouse serum and brain

Treatment (mg/kg)		Caffeine concentration
Twice daily for 14 days	15th day	Serum (­μg/ml)	Brain (ng/g)
Caffeine 5	Caffeine 5 + saline	3.030 ± 0.3710	1079 ± 180.9
Caffeine 5	Caffeine 5 + agomelatine 20	3.706 ± 0.1589	2447 ± 326.1**
Caffeine 5	Caffeine 5 + mianserin 10	4.229 ± 0.1479**	861.8 ± 61.58

Each experimental group consisted of 8–10 animals. Results are presented as mean values ± SEM

**p < 0.01, compared with the respective control group (Student’s t test)