Fig. 5.

Glucose tolerance and insulin sensitivity. a Intraperitoneal glucose tolerance test (IPGTT). b Area under the curve of IPGTT. c Insulin tolerance test (ITT). d Area under the curve of the ITT. Results are means ± SEM, n = 6. Comparisons were performed by two-way ANOVA, Bonferroni post hoc. *p < 0.05, **p < 0.01 and ***p < 0.001 significant between control mice fed with fat diet vs. control mice fed standard diet; $p < 0.05 and $$p < 0.01 significant between control mice fed with fat diet vs. mice treated with pitolisant; ^p < 0.05 significant between control mice fed with standard diet vs. mice treated with pitolisant; #p < 0.05 and ##p < 0.01 significant between control mice fed with standard diet vs. mice treated with metformin; +p < 0.05 significant between control mice fed with fat diet vs. mice treated with metformin