Table 1.

Two antibiotic exposure simulations with daily cycling between antibiotic 1 and antibiotic 2 for 1 day and 3 day cycling protocols

Min growth rate ${\psi }_{{\min }_1}$	Min growth rate ${\psi }_{{\min }_2}$	Hill coefficient β	Drug classification	Tfix@ c =3 µg mL−1 (1 day, 3 days)	Tfix@ c =10 µg mL−1 (1 day, 3 days)
−1	−1	3	Static/Static	67 hours, 102 hours	95 hours, 113 hours
−1	−3	3	Static/Cidal	67 hours, 101 hours	90 hours, 107 hours
−3	−1	3	Cidal/Static	68 hours, 101 hours	90 hours, 112 hours
−3	−3	3	Cidal/Cidal	68 hours, 101 hours	87 hours, 107 hours
−1	−1	1	Static/Static	96 hours, 115 hours	438 hours, >1,000 hours
−1	−3	1	Static/Cidal	90 hours, 110 hours	294 hours, 1,198 hours
−3	−1	1	Cidal/Static	90 hours, 115 hours	233 hours, 1,124 hours
−3	−3	1	Cidal/Cidal	85 hours, 109 hours	237 hours, 523 hours

Notes: Cidal denotes a bactericidal antibiotic, while Static denotes a bacteriostatic antibiotic. We report resistance fixation T_fix in each simulation.