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. 2018 Jun 9;46(13):6683–6696. doi: 10.1093/nar/gky476

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Firing origins are generally of low density but are enriched upstream of TSSs in common fragile sites. (A) Average number of sMCM7 (total origins), firing origins and dormant origins within the indicated genes (per 100 kb). (B) Relative co-localization frequencies of the different replication timing regions with the indicated genes. Values obtained with shuffled genes are set at 1. (C) Number of firing origins surrounding TSSs of CFSs. (D) Selected snapshots of the genome browser view around the FHIT and DPYD CFS loci. Visual representations of FAIRE-Seq, DNase-Seq, firing origin and dormant origin data from HeLa cells. (E) Aggregation plots of FAIRE-Seq signals surrounding TSSs of the indicated genes.