Figure 3.

Competitive release—comparative performance of clone R in competition in the presence (blue lines) and absence (black lines) of drug treatment. (A) Geometric mean asexual parasite density of clone R at different initial parasite dosages. (B) Duration of infection of resistant parasites (time to last detection by qPCR) for the different R inoculum sizes. Each line represents the duration of one single infection. (C) Duration of infectious period (from first to last detection of gametocytes by qPCR) for the different R inoculum sizes. Diamonds represent infections that did not produce any gametocytes. (D) Mean transmission probability per day at different initial parasite dosages based on a gametocyte density-infectivity function [65]. Data in (A) and (D) are means (±SEM) from the post-treatment infection period (Days 10–49 PI) of up to five mice (R inoculum sizes 10⁶, 10⁵, 10³) or up to 10 mice (inoculum size 10¹; Table 1)