Table 2.

Various proxies of absolute fitness calculated for each infection for sensitive, resistant or all parasites and throughout the infection, during treatment or after treatment, as stated in the main text

Variable	Quantitative definition	Unit
Initial growth rate	Slope of regression of parasite density by time for Days 3–6 post-infection	Daily fold-increase
Parasite density	Sum of asexual parasite densities, either throughout the infection (Days 0–49) or post-treatment (Days 10–49)	106 parasites/µl blood (whole infection) or 104 parasites/µl blood (post-treatment)
Parasite persistence	Day post-infection of last detectable asexual parasites by PCR from either start of the infection or after treatment ended	Days
Infectious period	Number of days of detection of gametocytes by PCR from either first to last day of detection or from at minimum end of treatment to last detection of gametocytes	Days
Infectiousness	Mean daily probability of onwards transmission to mosquitoes each day, predicted from gametocyte density-infectivity function described by [65] calculated either throughout the infection (Days 0–49) or post-treatment (Days 10–49)	Probability