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. 2018 Jun 7;46(13):6697–6711. doi: 10.1093/nar/gky487

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — An Orc1-2-centered network of DNA damage response in S. islandicus. DNA damage agents yield lesions on DNA that will be converted into double-stranded breaks, which activate the DNA damage signal transduction pathway in this archaeon. Then, the global regulator, Orc1-2 is probably activated by posttranslational modifications, such as phosphorylation and/or acetylation. The activated form of Orc1-2 then recognizes DDRE present in the promoters of DDR genes and activates or represses their expression, including several different cellular processes as well as its own gene. AAA+: ATPases associated with diverse cellular activities; wH: wing-helix DNA binding domain; DDRE: DNA damage-responsive element; BRE: Transcriptional factor B (TFB) recognition element; TATA; TATA box serving as the binding site for TATA-binding protein (TBP); TTS: transcription start site; Ups: UV-responsive pili of Sulfolobus; Ced: Crenarchaeal system for exchange of DNA.