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. 2018 Apr 30;46(13):6806–6822. doi: 10.1093/nar/gky287

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Knockdown of mismatched targets by sli-siRNA-ARX, siRNA-ARX and dsiRNA-ARX at five different concentrations. (A) Nucleotide sequences of siRNA-ARX (si-), sli-siRNA-ARX (sli-) and dsiRNA-ARX (dsi-) molecules. (B) Knockdown efficiency of the fully complementary WT reporter and two position 14C mutated reporters (C14A and C14G) by sli-siRNA-ARX (sli-), siRNA-ARX (si-) and dsiRNA-ARX (dsi-) in HEK-293 cells. (C) Knockdown of WT, C14A and C14G reporters co-transfected with an hAgo2 expression plasmid, and RNAi reagents into MEF Ago2 KO cells. Normalized relative Rluc/Fluc ratios are plotted against the concentrations of each RNAi in pM. Error bars represent standard deviation of the mean.