Table 10. Effect of eriodictyol on glutathione and glutathione-dependent enzymes in the colonic tissue levels of control and experimental rats.
| Parameters and samples | Groups |
|||||
| Control | DMH | Eriodictyol | Initiation | Post-initiation | Entire period | |
| GPX a | ||||||
| Proximal colon | 7.21 ± 0.03a | 3.55 ± 0.02b | 8.11 ± 0.21c | 5.34 ± 0.17d | 6.38 ± 0.18e | 6.72 ± 0.16e |
| Distal colon | 7.25 ± 0.17a | 3.54 ± 0.48b | 8.09 ± 0.26c | 5.45 ± 0.35d | 5.61 ± 0.41d | 6.81 ± 0.71e |
| Intestine | 7.20 ± 0.44a | 3.24 ± 0.07b | 8.04 ± 0.32c | 5.29 ± 0.37d | 5.33 ± 0.04d | 6.01 ± 0.08e |
| GST b | ||||||
| Proximal colon | 4.03 ± 0.18a | 1.99 ± 0.04b | 4.11 ± 0.14a | 2.88 ± 0.14c | 3.14 ± 0.09d | 3.52 ± 0.05d |
| Distal colon | 4.07 ± 0.05a | 1.98 ± 0.43b | 4.12 ± 0.04a | 2.90 ± 0.43c | 3.14 ± 0.08d | 3.55 ± 0.09e |
| Intestine | 3.95 ± 0.52a | 1.98 ± 0.09b | 4.08 ± 0.14c | 2.80 ± 0.31d | 3.11 ± 0.02e | 3.52 ± 0.11e |
| GSH c | ||||||
| Proximal colon | 4.12 ± 0.08a | 1.85 ± 0.15b | 4.26 ± 0.36a | 3.21 ± 0.42c | 3.86 ± 0.41d | 4.09 ± 0.65e |
| Distal colon | 4.16 ± 0.22a | 1.84 ± 0.51b | 4.29 ± 0.13a | 3.21 ± 0.05c | 3.85 ± 0.37d | 4.12 ± 0.11e |
| Intestine | 4.09 ± 0.20a | 1.80 ± 0.39b | 4.23 ± 0.08a | 3.19 ± 0.62c | 3.82 ± 0.07d | 4.02 ± 0.38e |
| GR d | ||||||
| Proximal colon | 41.62 ± 0.47a | 29.54 ± 0.83b | 43.67 ± 0.42a | 36.32 ± 0.46c | 37.75 ± 0.62c | 40.72 ± 0.34d |
| Distal colon | 42.13 ± 0.08a | 28.42 ± 0.63b | 43.18 ± 0.44a | 36.62 ± 0.81c | 38.22 ± 0.34c | 39.12 ± 0.05d |
| Intestine | 41.30 ± 0.42a | 28.03 ± 0.19b | 42.65 ± 0.18a | 36.23 ± 0.09c | 37.33 ± 0.15c | 37.62 ± 0.12c,d |
aμmoles of GSH utilized per min per mg protein.
bμmoles of CDNB-GSH conjugate formed per min per mg protein.
cmmol per mg tissue protein.
dμmoles of NADPH oxidized per min per mg protein.