Table 3. Effect of eriodictyol on aberrant crypt foci formation, crypt multiplicity and percentage inhibition in the colon of control and experimental rats.
Groups | No. of rats/no. of ACF-bearing rats | Total number of ACF | Crypt multiplicity |
% Inhibition | ||
1 crypt | 2 crypts | >3 crypts | ||||
Control | 8/0 | Nil | Nil | Nil | Nil | — |
DMH | 8/8 | 62.37 ± 9.79a | 28.21 ± 4.21a | 12.53 ± 2.12a | 21.63 ± 3.46a | — |
Eriodictyol | 8/0 | Nil | Nil | Nil | Nil | — |
Initiation | 8/8 | 52.58 ± 8.83b | 25.32 ± 4.01b | 10.98 ± 1.96b | 16.28 ± 2.86b | 9.97 |
Post-initiation | 8/8 | 29.52 ± 4.83c | 20.45 ± 3.26c | 9.07 ± 1.57c | — | 32.85 |
Entire period | 8/8 | 17.26 ± 2.97d | 17.26 ± 2.97d | — | — | 45.11 |