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Schematic diagram. A model describing the function of Cdk1 as an upstream regulator for Oct4 phosphorylation. Cdk1 controls the activities of Aurkb/CPC and PP1, leading to dissociation of Oct4 from chromatin during mitosis. Abnormal inhibition of Cdk1 at mitosis triggers chromosome decondensation, Oct4(S229) dephosphorylation, and evokes Oct4 transcriptional activity.
