Figure 5.

The claustrum network links diverse causes and treatments of parkinsonism. (A) Connectivity with the claustrum (middle) defines a brain network (red) that encompasses lesion locations casing parkinsonism (purple) and areas of atrophy in parkinsonism syndromes (blue–purple). (B) Connectivity between the claustrum and STN DBS electrode location correlates with clinical improvement in patients with Parkinson’s disease. Clau = claustrum; Fz = Fisher’s z; PD = Parkinson’s disease; UPDRS-III = Unified Parkinson’s Disease Rating Scale, motor score; VTA = volume tissue activation.