Table 3. mRNA and protein levels of CYP1A1 and 1A2 and activities of CYP450s and GSTs in rat lungs treated with PM2.5 or 9-NA.
Groups | CYP1A1 mRNA (changed fold) | CYP1A1 protein (ng mg–1 protein) | CYP1A2 mRNA (changed fold) | CYP1A1 protein (ng mg–1 protein) | GST (U mg–1 protein) | CYP450 (U mg–1 protein) |
Control | 1.00 ± 0.26 | 22.7 ± 3.9 | 1.00 ± 0.32 | 2 ± 0.14 | 26.1 ± 2.5 | 0.071 ± 0.008 |
PM2.5 | 1.44 ± 0.25* | 29.7 ± 4* | 1.31 ± 0.29 | 2.61 ± 0.3** | 34.8 ± 4.3** | 0.103 ± 0.016* |
9-NA-1 | 1.25 ± 0.27 | 25.5 ± 4.4 | 1.16 ± 0.31 | 2.17 ± 0.2 | 29 ± 3 | 0.079 ± 0.013 |
9-NA-2 | 1.47 ± 0.37* | 27.4 ± 4.2 | 1.38 ± 0.34 | 2.23 ± 0.28 | 32.4 ± 3** | 0.086 ± 0.01 |
9-NA-3 | 1.59 ± 0.46* | 31.1 ± 4.9* | 1.44 ± 0.32* | 2.68 ± 0.21** | 36.5 ± 3.3** | 0.12 ± 0.037** |