Fig 4. DSM I_BK and I_IK model.

(A) DSM cell I_BK model. Fig 4A represents the normalized simulated current-voltage curve (solid line), where experimental data from murine DSM cell [80] are superimposed in filled square. Fig 4B represents the effects of intracellular Ca²⁺ concentration on shifting the current-voltage curve. The [Ca²⁺]_i is varied from the control value of 0.0001 mM (solid line) to 0.00001 mM (dashed line) and 0.001 mM (dot and dash line). (C) The solid line represents the normalized simulated I_IK current-voltage curve, where experimental data from mouse intestinal cell [81] are superimposed in filled triangle. (D) It represents open probability of α-subunits with respect to varying [Ca²⁺]_i in I_IK model.