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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Apr 6;9(6):1327–1337. doi: 10.1021/acschemneuro.7b00510

Figure 2. L-SPD acts as an antagonist at the D2 and D3 receptor.

Figure 2.

Dopamine (DA), but not L-SPD, stimulated [35S]GTPγS binding in CHO cells expressing D2 or D3 receptors at doses of 10 μM (a). L-SPD at 1 μM shifted the dose-response curve of DA to the right and increased the EC50 value of DA by 21-fold at the D2R, and 50-fold at the D3R (b). Potencies and efficacies were determined by curve fitting and are shown in Table 3. Data represent mean ± S.E.M. (n = 4–5). ***p < 0.001 relative to Basal using one-way ANOVA with Bonferroni post-hoc tests.