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. Author manuscript; available in PMC: 2019 Jun 20.
Published in final edited form as: ACS Chem Neurosci. 2018 Apr 6;9(6):1327–1337. doi: 10.1021/acschemneuro.7b00510

Figure 4. L-SPD dose-dependently attenuates cue plus MDPV-primed reinstatement of MDPV-seeking behavior in the IVSA model.

Figure 4.

Data for acquisition (ACQ) and extinction (EXT) training was based on average performance across the last 3 days of each phase. EXT significantly reduced active lever responses in comparison to ACQ (p < 0.01) (a). L-SPD at 10 mg/kg (p < 0.01), but not 1 or 3 mg/kg (both p > 0.05), significantly reduced active lever presses during reinstatement testing (a). However, L-SPD did not significantly affect responses on the inactive lever (b). Data are shown as mean + S.E.M. (n = 11). ++p < 0.01 relative to ACQ; **p < 0.01 relative to vehicle (VEH).