. Author manuscript; available in PMC: 2019 Jun 20.

Published in final edited form as: ACS Chem Neurosci. 2018 Apr 6;9(6):1327–1337. doi: 10.1021/acschemneuro.7b00510

Table 2.

Potencies (EC₅₀) and efficacies (E_max) of dopamine (DA) and L-SPD in stimulating D1 or D5 receptors to enhance cAMP formation in HEK cells expressing the human D1 or D5 receptor. Each value represents mean ± S.E.M. (n = 3–4).

	D1R			D5R
	Log[EC₅₀(M)]	EC₅₀ (μM)	E_max (% of 10⁻⁵ M DA response) [fold of basal]	Log[EC₅₀(M)]	EC₅₀ (μM)	E_max (% of 10⁻⁵ M DA response) [fold of basal]
DA	−7.01 ± 0.20	0.098 ± 0.046	108.1 ± 9.7 [17.4]	−6.69 ± 0.12	0.20 ± 0.06	108.4 ± 5.3 [25.5]
L-SPD	−7.68 ± 0.12	0.021 ± 0.006	108.8 ± 4.0 [17.5]	−7.20 ± 0.28	0.063 ± 0.043	23.6 ± 2.0^*** [6.5]

^***

p < 0.001 compared to DA using t-tests.