. Author manuscript; available in PMC: 2019 Jun 20.

Published in final edited form as: ACS Chem Neurosci. 2018 Apr 6;9(6):1327–1337. doi: 10.1021/acschemneuro.7b00510

Table 3.

Effects of the presence of 1 μM of L-SPD on potency (EC₅₀) and efficacy (E_max) of dopamine (DA) in stimulating D2 or D3 receptors to enhance [³⁵S]GTPγS binding in CHO cells expressing the human D2 or D3 receptor. Basal [³⁵S]GTPγS binding values were ~2000–3000 dpm. Each value represents mean ± S.E.M. (n = 3–5).

	D2R			D3R
	Log[EC₅₀(M)]	EC₅₀ (μM) [Fold of DA]	^E_max(% of basal)	Log[EC₅₀(M)]	EC₅₀ (μM) [Fold of DA]	^E_max(% of basal)
DA	−6.08 ± 0.08	0.83 ± 0.14 [1]	168.1 ± 1.6	−7.30 ± 0.24	0.042 ± 0.019 [1]	142.5 ± 2.9
DA + L-SPD 1 μM	−4.75 ± 0.19^***	17.6 ± 7.9^* [21]	140.6 ± 3.8^***	−5.68 ± 0.30^**	2.08 ± 1.04^* [50]	139.9 ± 9.3

^***

p < 0.001

^**

p < 0.01

p < 0.05, relative to DA by t-tests.