Table 2. Mean levels of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M1dG) adducts per 108 normal nucleotides in the nasal epithelia of workers occupationally exposed to formaldehyde compared to the controls, and according to study variables.
Nasal epithelia M1dG adducts | |||
N | Mean levels ± SE | P-values a | |
Age | |||
<42 years b | 31 | 90 ± 15 | |
42–49 years | 35 | 87 ± 16 | 0.841 |
>49 years | 29 | 68 ± 10 | 0.492 |
P-value for trend | 0.348 | ||
Tobacco smoking | |||
Non-smokers b | 57 | 82.4 ± 11 | |
Smokers | 38 | 82.0 ± 12 | 0.637 |
Jobs | |||
Controls b | 45 | 49.6 ± 3.4 | |
Plastic laminate plant workers | 50 | 111.6 ± 14.3 | <0.001 |
Personal formaldehyde exposure | |||
<25 b μg m–3 | 23 | 47.6 ± 4.4 | |
25–66 μg m–3 | 19 | 59.2 ± 11.6 | 0.703 |
>66 μg m–3 | 53 | 105.5 ± 13.4 | 0.001 |
P-value for trend | 0.002 |
a P-values after adjusting for confounding factors.
bReference level.