. 2016 Apr 28;5(4):1115–1121. doi: 10.1039/c6tx00016a

Table 1. NNK reduction and its metabolites by a CYP2A13- and 2A6-catalyzed reaction ^a .

	Control (μM)	2A13 (μM)	2A6 (μM)
NNK	10.41 ± 0.20	4.33 ± 0.29	10.04 ± 0.20
OPB	0	0.96 ± 0.032	— ^b
HPB	0	1.76 ± 0.012	— ^b
OPBA	0	0.46 ± 0.015	— ^b

^aIndicates that the enzymatic reaction was performed at 37 °C for 10 min with 25 pM CYP2A13 (or 50 pM CYP2A6), 10 μM NNK, NADPH-generating system and 3 mM MgCl₂ in 0.1 mM Tris buffer at pH 7.4. Values are means ± SD (n = 3).

^bRepresents the metabolites level was under the limit of quantitation in the recent analytical method.

Table 1. NNK reduction and its metabolites by a CYP2A13- and 2A6-catalyzed reaction a .

Table 1. NNK reduction and its metabolites by a CYP2A13- and 2A6-catalyzed reaction ^a .