Table 1. Dietary models of steatosis and steatohepatitis in rodents.
Models | Kcal from fat in diet | Added sugars in water | Treatment duration (week) | Obesity | Insulin resistance | Steatosis | Lobular inflammation | Hepatocytes ballooning | Perisinusoidal fibrosis | HCC | Ref. |
MCD | 20% | – | Up to 52 | – | – | + | + | + | + | – | 48 |
CD-HFD | NP | – | 48 | + | NP | + | + | + | + | + | 49 |
HFD | 60% | – | Up to 50 | + | + | + | + | – | + | – | 50 |
HFTFD | 58% | + | 16 | + | + | + | + | + | + | – | 58 |
ALIOS | 45% | + | Up to 16 | + | + | + | + | + | – | – | 54 |
HFD32 | 64% | – | 60 | + | + | + | + | – | + | + | 50 |
AMLN | 40% | + | Up to 30 | + | + | + | + | + | + | – | 56 |
WD | 42% | – | Up to 60 | + | + | + | + | – | + | + | 52 |
WD | 42% | + | Up to 52 | + | + | + | + | + | + | + | 58 |