Table 2. Drugs induced steatosis and steatohepatitis.

Chemicals	Hepatic effects	Potential mechanism	Ref.
Tamoxifen	Steatosis/steatohepatitis	Increase fatty acids biosynthesis	65
Amiodarone	Steatosis/steatohepatitis	Inhibit mitochondrial fatty acid oxidation	55
Valproic acid	Steatosis	Induce metabolic disorders; impair mitochondrial functions	57
Tetracyclines a	Steatosis	Upregulate lipogenic genes	61
Methotrexate	Steatosis/steatohepatitis	Induce oxidative stress	63 and 64
Corticosteroids	Steatosis	Inhibit mitochondrial fatty acid oxidation; increase de novo fatty acids synthesis	55

^aTetracyclines compounds, including tetracycline, doxycycline and minocycline, may induce acute microvesicular steatosis.