Table 3. Selective nuclear receptor mediated chemicals and their effect on NAFLD.

Chemicals	Nuclear receptor	Effects on NAFLD	Ref.
Perfluoroalkyl acids (PFOA, PFOS, PFNA, etc.)	PPARα, CAR, PXR	Steatosis, inflammation, cell proliferation	84–87
Phalates(DEHP)	PPARα, PPARγ	Steatosis, inflammation, oxidative stress, cell proliferation	94–97
Dioxins(TCDD)	AhR	Steatosis, inflammation, cell proliferation	98–102
Polychlorinated biphenyls	CAR, PXR, AhR	Steatosis, inflammation	105–108
Cyclodienes	CAR, PXR	Steatosis	109–111
Trichloroethylene and perchloroethylene	PPARα, PPARγ	Steatosis, inflammation, cell cycle	113, 117 and 118
Vinyl chloride	PPARα	Steatosis, inflammation, cell death	69