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. 2018 Jul 26;13(7):e0201056. doi: 10.1371/journal.pone.0201056

Fig 5. Functional enrichment results for the GSE15222 dataset.

Fig 5

An asterisk of a pathway and GO term indicates that it has been reported in previous studies. (A) We used GSEA with a FDR q-value threshold of 0.001 and selected 15 pathways that satisfy the threshold. Interestingly, several AD-related pathways, such as Regulation of actin cytoskeleton and Neurotrophin signalling pathway, were enriched as well as the Alzheimer’s disease pathway. (B) We used FuncAssociates 3.0 with the default evidence code. The p-value threshold was 0.001 and we selected 20 GO terms that are potentially related to AD. We found that many GO terms related to AD were significantly enriched. (C) We used GSEA with a FDR q-value threshold of 0.001 and selected 15 GO terms in the cellular component category that satisfy the threshold and are potentially related to neuronal functions.