. 2018 Jul 26;13(7):e0201453. doi: 10.1371/journal.pone.0201453

Table 2. Estimated mean and 95% confidence interval of each group in some temporal parameters of gait analysis.

Catwalk parameter	Paw/Side	Time (day)	Group Mean (95% CI)
Catwalk parameter	Paw/Side	Time (day)	Control (n = 4)	Sham (n = 4)	Tumor (n = 4)
Temporal parameters
Stand (s)	LH	0	0.43 (0.40; 0.46)	0.43 (0.41; 0.46)	0.45 (0.43; 0.48)
		7	0.43 (0.41; 0.46)	0.47 (0.45; 0.50)	0.50 (0.48; 0.52) ^#
		14	0.49 (0.47; 0.52)	0.45 (0.43; 0.47)	0.56 (0.52; 0.60)^* ^∞
		21	0.51 (0.49; 0.52)^*	0.46 (0.44; 0.48) ^#	0.71 (0.64; 0.78)^* ^# ^∞
		28	0.49 (0.47; 0.51)	0.45 (0.43; 0.47)	0.90 (0.79; 1.01)^* ^# ^∞
	RH	0	0.44 (0.43; 0.45)	0.44 (0.42; 0.47)	0.43 (0.41; 0.45)
		7	0.49 (0.47; 0.52)	0.42 (0.39; 0.44)^* ^#	0.50 (0.48; 0.53)^* ∞
		14	0.50 (0.47; 0.53)^*	0.48 (0.46; 0.50)	0.52 (0.48; 0.56)^*
		21	0.46 (0.44; 0.48)	0.48 (0.47; 0.50)	0.65 (0.59; 0.71)^* ^# ^∞
		28	0.48 (0.45; 0.52)	0.48 (0.46; 0.50)	0.80 (0.71; 0.90)^* ^# ^∞
	LF	0	0.30 (0.29; 0.31)	0.29 (0.28; 0.31)	0.33 (0.31; 0.34)
		7	0.37 (0.36; 0.38)^*	0.36 (0.34; 0.38)^*	0.38 (0.36; 0.39)^*
		14	0.35 (0.33; 0.37)^*	0.33 (0.31; 0.35)	0.46 (0.42; 0.49)^* ^# ^∞
		21	0.37 (0.35; 0.39)^*	0.38 (0.36; 0.40)^*	0.54 (0.49; 0.60)^* ^# ^∞
		28	0.34 (0.32; 0.35)^*	0.35 (0.33; 0.37)^*	0.71 (0.63; 0.79)^* ^# ^∞
	RF	0	0.29 (0.28; 0.30)	0.30 (0.29; 0.32)	0.31 (0.30; 0.33)
		7	0.36 (0.34; 0.37)^*	0.37 (0.36; 0.39)^*	0.33 (0.31; 0.34) ^∞
		14	0.35 (0.33; 0.37)^*	0.38 (0.36; 0.40)^*	0.45 (0.42; 0.48)^* ^# ^∞
		21	0.36 (0.34; 0.37)^*	0.34 (0.33; 0.36)	0.51 (0.47; 0.57)^* ^# ^∞
		28	0.34 (0.32; 0.35)^*	0.34 (0.33; 0.36)^*	0.64 (0.57; 0.72)^* ^# ^∞
Step cycle (s)	LH	0	0.48 (0.47; 0.49)	0.50 (0.48; 0.52)	0.47 (0.45; 0.50)
		7	0.48 (0.45; 0.51)	0.51 (0.49; 0.54)^*	0.61 (0.58; 0.64)^* ^# ^∞
		14	0.56 (0.54; 0.59)^*	0.55 (0.53; 0.57)^*	0.65 (0.61; 0.70)^* ^∞
		21	0.45 (0.43; 0.47)	0.54 (0.52; 0.56)^* ^#	0.78 (0.70; 0.86)^* ^# ^∞
		28	0.53 (0.51; 0.56)	0.53 (0.51; 0.56)	1.10 (0.97; 1.23)^* ^# ^∞
	RH	0	0.57 (0.54; 0.60)	0.53 (0.50; 0.55)	0.57 (0.54; 0.60)
		7	0.51 (0.49; 0.52)	0.51 (0.49; 0.54)	0.62 (0.59; 0.65) ^# ^∞
		14	0.53 (0.51; 0.55)	0.58 (0.55; 0.61)^* ^#	0.62 (0.58; 0.67)
		21	0.43 (0.41; 0.44)^*	0.52 (0.49; 0.55) ^#	0.73 (0.66; 0.81)^* ^# ^∞
		28	0.51 (0.48; 0.54)	0.54 (0.51; 0.56)	1.02 (0.90; 1.14)^* ^# ^∞
	LF	0	0.44 (0.42; 0.45)	0.38 (0.36; 0.41)	0.41 (0.39; 0.43)
		7	0.43 (0.41; 0.45)	0.45 (0.43; 0.48)	0.51 (0.49; 0.54)^* ^#
		14	0.50 (0.47; 0.52)^*	0.46 (0.44; 0.48)^*	0.60 (0.56; 0.65)^* ^# ^∞
		21	0.40 (0.39; 0.41)^*	0.45 (0.44; 0.47)^* ^#	0.71 (0.65; 0.79)^* ^# ^∞
		28	0.48 (0.45; 0.51)	0.51 (0.49; 0.54)^*	0.99 (0.88; 1.12)^* ^# ^∞
	RF	0	0.44 (0.42; 0.47)	0.40 (0.38; 0.43)	0.45 (0.43; 0.47)
		7	0.39 (0.38; 0.40)	0.50 (0.48; 0.52)^* ^#	0.49 (0.47; 0.52) ^#
		14	0.47 (0.44; 0.49)^*	0.48 (0.45; 0.51)	0.59 (0.55; 0.64)^* ^# ^∞
		21	0.46 (0.44; 0.48)	0.47 (0.45; 0.49)^*	0.70 (0.63; 0.77)^* ^# ^∞
		28	0.47 (0.45; 0.48)	0.55 (0.53; 0.58)^* ^#	1.00 (0.89; 1.12)^* ^# ^∞
Cadence (step/s)		0	7.89 (7.52; 8.29)	8.77 (8.34; 9.23)	8.32 (7.92; 8.75)
		7	8.61 (8.17; 9.07)^*	7.51 (7.15; 7.89) ^#	7.38 (7.02; 7.76)^* ^#
		14	8.28 (7.93; 8.64)	7.19 (6.83; 7.56)^* ^#	6.77 (6.28; 7.29)^* ^#
		21	7.98 (7.63; 8.34)	8.93 (8.51; 9.37) ^#	5.51 (4.99; 6.08)^* ^# ^∞
		28	7.87 (7.56; 8.20)	7.34 (6.99; 7.72)^*	3.99 (3.61; 4.41)^* ^# ^∞
Duration (s)		0	3.78 (3.61; 3.96)	3.49 (3.33; 3.66)	4.05 (3.86; 4.25) ^∞
		7	4.33 (4.11; 4.56)	3.20 (3.05; 3.36) ^#	4.79 (4.57; 5.03)^* ^#
		14	3.92 (3.73; 4.12)	4.65 (4.44; 4.87)^* ^#	5.24 (4.87; 5.64)^* ^#
		21	5.09 (4.88; 5.30)^*	4.02 (3.82; 4.23)^* ^#	7.95 (7.21; 8.77)^* ^# ^∞
		28	3.86 (3.67; 4.06)	4.29 (4.08; 4.51)^*	10.10 (9.17;11.12)^* ^# ^∞

Abbreviations: RF, right forepaw; RH, right hindpaw; LF, left forepaw; LH, left hindpaw.

Multiple comparison analysis corrected by Bonferroni for time and groups.

* p < 0.001 in comparison to base time

# p < 0.001 in comparison to control group

∞ p < 0.001 in comparison to sham group