Table 2. Descriptives for Tian Tian’s (SB569) reproductive cycle: USpG-, creatinine-corrected and raw metabolite concentration, USpG-values and creatinine concentrations in urine, faecal output and bodyweight.
| Anoestrus (min-max: D-208-D-9) |
Pro-oestrus (min-max: D-14-D0) |
Postoestrus (min-max:D1-D7) |
Primary P4 rise (min-max:D8-D128) |
Secondary P4 rise (min-max: D98-D179) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (stdev) | Median (range) | Mean (stdev) | Median (range) | Mean (stdev) | Median (range) | Mean (stdev) | Median (range) | Mean (stdev) | Median (range) | |
| Oestrogens | (n = 449/526) | (n = 92/123) | (n = 26/50) | (n = 447/525) | (n = 203/247) | |||||
| USpG (ng/mL) | 1.44 (0.54) | 1.37 (0.55–4.58)a | 30.13 (21.10) | 27.86 (2.13–86.93)c | 11.80 (18.66) | 2.35 (0.31–65.12)b | 1.05 (0.40) | 0.99 (0.35–3.21)a | 1.58 (0.70) | 1.50 (0.22–4.20)a |
| Creatinine (ng/mg Cr) | 2.11 (1.07) | 1.87 (0.66–13.64)a | 14.31 (7.97) | 14.05 (2.33–31.20)c | 7.79 (8.70) | 2.75 (0.28–27.49)b | 1.77 (0.89) | 1.60 (0.52–10.31)a | 1.61 (1.02) | 1.40 (0.25–7.98)a |
| Raw (ng/ mL) | 1.72 (2.06) | 1.17 (0.06–34.11)a | 87.62 (80.92) | 65.78 (0.43–350.1)c | 44.95 (68.59) | 6.51 (0.51–244.2)b | 0.93 (0.60) | 0.78 (0.14–4.43)a | 2.39 (1.92) | 1.92 (0.14–12.59)a |
| Progesterone | (n = 176/526) | (n = 35/123) | (n = 14/50) | (n = 347/525) | (n = 169/247) | |||||
| USpG (ng/mL) | 5.24 (1.87) | 4.9 (1.39–14.08)a | 3.04 (1.01) | 2.79 (1.81–5.80)a | 5.01 (2.09) | 4.56 (1.95–8.29)a | 13.89 (6.10) | 12.56 (5.14–47.95)a | 62.73 (40.33) | 54.35 (3.26–280.5)b |
| Creatinine (ng/mg Cr) | 8.40 (3.59) | 7.29 (2.89–24.38)a | 2.07 (1.38) | 1.63 (0.93–9.08)a | 4.15 (2.81) | 3.20 (1.11–11.05)a | 25.36 (16.73) | 20.05 (4.88–152.4)b | 65.19 (56.70) | 55.23 (1.82–578.9)c |
| Raw (ng/ mL) | 5.04 (3.26) | 4.19 (0.57–24.60)a | 7.33 (3.79) | 6.76 (1.21–16.89)a | 12.66 (8.39) | 11.89 (0.87–35.00)a | 11.21 (5.89) | 9.83 (2.13–38.14)a | 89.37 (77.63) | 75.86 (0.46–436.3)b |
| Ceruloplasmin | (n = 174/526) | (n = 37/123) | (n = 12/50) | (n = 418/525) | (n = 183/247) | |||||
| USpG (ng/mL) | 9.84 (13.10) | 5.00 (0.05–90.60)a | 11.29 (8.35) | 12.08 (0.08–30.31)a | 17.22 (11.32) | 9.76 (6.33–30.70)a,b | 33.08 (26.27) | 27.36 (0.05–156.1)b | 10.21 (13.38) | 6.00 (0.00–82.00)a |
| Creatinine (ng/mg Cr) | 15.24 (24.87) | 6.06 (0.07–189.38)a | 6.24 (4.62) | 5.81 (0.04–15.54)a | 22.59 (19.89) | 14.91 (2.44–71.29)a | 64.97 (84.20) | 48.69 (0.06–1319)b | 17.33 (36.11) | 5.82 (0.00–255.3)a |
| Raw (ng/ mL) | 10.85 (12.99) | 5.00 (0.00–69.20)a | 28.85 (20.90) | 29.10 (0.10–78.00)b,c | 34.54 (26.91) | 25.60 (5.57–108.9)c | 24.44 (18.44) | 21.80 (0.00–136.6)b | 12.25 (12.05) | 7.65 (0.00–57.02)a |
| PGFM | (n = 10/526) | (n = 32/123) | (n = 11/50) | (n = 157/525) | (n = 189/247) | |||||
| USpG (ng/mL) | 10.87 (5.47) | 9.68 (3.72–22.30)a,b | 28.81 (17.19) | 22.63 (7.79–83.79)a,b | 25.57 (28.73) | 16.38 (3.96–101.8)a,b | 5.67 (3.40) | 4.60 (0.0–16.41)a | 36.75 (45.19) | 15.1 (1.89–308.1)b |
| Creatinine (ng/mg Cr) | 14.07 (8.26) | 11.68 (5.02–32.87)a | 14.93 (6.05) | 13.07 (7.82–32.13)a | 13.40 (9.88) | 10.53 (5.53–41.75)a | 10.49 (8.28) | 7.80 (1.91–52.38)a | 29.96 (50.01) | 15.79 (2.31–536.49)a |
| Raw (ng/ mL) | 19.40 (17.55) | 14.53 (3.25–61.33)a,b | 78.81 (60.85) | 62.58 (13.63–261.8)c | 54.44 (96.48) | 21.10 (0.86–381.7)a,b,c | 4.67 (4.54) | 3.29 (0.81–39.0)a | 58.66 (75.01) | 20.81 (0.00–318.3)b,c |
| USpG | (n = 497/526) | (n = 94/123) | (n = 31/50) | (n = 509/525) | (n = 221/247) | |||||
| USpG | 1.009 (0.006) | 1.007 (1.000–1.034)a | 1.021 (0.007) | 1.023 (1.002–1.037)c | 1.019 (1.011) | 1.022 (1.000–1.033)c | 1.007 (0.004) | 1.006 (1.000–1.024)a | 1.012 (0.008) | 1.011 (1.001–1.042)b |
| Cr | (n = 525/526) | (n = 123/123) | (n = 48/50) | (n = 518/525) | (n = 244/247) | |||||
| Creatinine (mg/mL) | 0.87 (0.75) | 0.66 (0.00–4.64)a | 5.33 (3.14) | 4.92 (0.00–13.23)d | 4.11 (2.76) | 4.09 (0.03–10.13)c | 0.56 (0.45) | 0.47 (0.00–3.50)a | 1.91 (2.17) | 1.27 (0.00–13.42)b |
| Faeces | (n = 451/526) | (n = 37/123) | (n = 17/50) | (n = 451/525) | (n = 193/247) | |||||
| Faeces (kg) | 3.72 (1.42) | 3.70 (0.90–7.50)b | 1.43 (0.79) | 1.30 (0.20–3.90)a | 2.56 (1.65) | 1.60 (1.00–5.70)a,b | 8.66 (2.16) | 8.80 (1.60–15.90)c | 3.70 (3.18) | 2.50 (0.20–13.80)b |
| Bodyweight | (n = 437/526) | (n = 16/123) | (n = 9/50) | (n = 448/525) | (n = 84/247) | |||||
| Bodyweight (kg) | 107.5 (2.04) | 107.5 (102.0–112.0)b | 103.9 (2.01) | 104.1 (99.7–107.0)a,b | 101.2 (2.04) | 102.0 (98.5–104.0)a | 111.9 (5.6) | 112.2 (100.6–126.5)c | 114.9 (4.4) | 115.5 (105.0–123.4)c |
Stdev = standard deviation; n = number of samples; USpG = urinary specific gravity; cr = creatinine.
a-d = different superscripts (a-d; ascending; horizontally) indicate significant differences for the respective metabolite levels between each defined reproductive period; Independent-Samples Kruskall Wallis test with post hoc Dunn’s comparison; significant if p < 0.05.