Table 10. Metabolism of the cellular matrix in cartilage.

Ref.	Sources	Interventions		Outcomes
		T-2 toxin	Time	MMPs	ILs, TNFs	Collagens	PG, PG components
Mo et al. 199488	Wistar rats	0.2 mg per kg BW per 2 d	100 d			Total collagen↓ (SP)	Sulfate groups↓ (SP) , hexosamine↓ (SP), glucuronic acid↓ (SP)
Kang et al. 200959	Wistar rats	1 mg per kg BW per d	2, 4 w			Total collagen↓ (MS)
Wang et al. 200960	Wistar rats	100 ng g–1	3, 6 m			Collagen fibers appear↑ (W/VG), collagen fibers breakage and desquamation↑ (SEM)	PG↓ (SEM)
Yan et al. 201063	Wistar rats	0.04 mg kg–1 d–1	1, 2, 4 w			Total collagen↓ (MS)
Yao et al. 201061	Wistar rats	1 mg per kg BW per d	2, 4 w			Total collagen↓ (MS)
Yao et al. 201062	Wistar rats	10 mg per kg BW per d	4 w			Total collagen↓ (MS)
Meng et al. 201164	Wistar rats	100, 200, 300 μg kg–1	6 m			Collagen fibers breakage↑ (SEM)	PG↓ (SEM)
Kang et al. 201368	Wistar rats	0.1 mg per kg BW per d	8, 12 w			Total collagen↓ (MS)
Chen et al. 201073	SD rats	100, 200 ng per g BW per d	12 w			Fibrils appear↑ (HE)
Guan et al. 201375	SD rats	100, 200 ng per g BW per d	4 w				sGAG↓ (TB)
Chen et al. 201416	SD rats	100 μg per kg BW per d	30 d	MMP-13↑ (IH)
Zhou et al. 201476	SD rats	100, 200 ng per g BW per d	4 w		IL-6↑, IL-lβ↑, TNF-α↑, IL-6 mRNA↑, IL-lβ mRNA↑ TNF-α mRNA↑		sGAG↓ (TB)
Hu et al. 199689	Chicks	0.4 mg per kg BW	9 w			Type I↑, type II↓ (IH)	Keratan sulfate↓, chondroitin sulfate↓ (HC)
Wang et al. 200681	Chicks	100, 600 μg per kg BW per d	5 w			Type II↓ (W/VG)	PG↓ (AB)