Table 3.
Crude odds ratios for being a false positive adherer by self-reported measurements of medication adherence in newly treated hypertensive patients.
| Type of self-reported measurement of adherence | ||||||
|---|---|---|---|---|---|---|
| MARS | Previous Month Reported Adherence |
Previous Week Reported Adherence |
||||
| Predictors | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value |
| Age (>50 years) | 1.12 (0.64, 1.93) | 0.69 | 1.16 (0.70, 1.93) | 0.57 | 1.14 (0.65, 1.99) | 0.66 |
| Female | 0.92 (0.53, 1.60) | 0.77 | 1.06 (0.64, 1.76) | 0.82 | 1.09 (0.63, 1.89) | 0.76 |
| Non-Whites | 0.92 (0.32, 2.63) | 0.88 | 1.04 (0.43, 2.51) | 0.92 | 1.22 (0.48, 3.10) | 0.67 |
| Less than high school | 1.37 (0.78, 2.38) | 0.27 | 1.53 (0.93, 2.51) | 0.09 | 1.68 (0.98, 2.90) | 0.06 |
| Unmarried | 0.92 (0.46, 1.81) | 0.80 | 0.92 (0.49, 1.75) | 0.81 | 1.03 (0.51, 2.06) | 0.94 |
| Annual income (<$16,000) | 1.76 (0.64, 4.81) | 0.27 | 1.54 (0.64, 3.70) | 0.34 | 1.46 (0.51, 4.19) | 0.48 |
| Heavy drinkersa | 1.27 (0.72, 2.24) | 0.41 | 1.23 (0.73, 2.09) | 0.44 | 1.15 (0.64, 2.05) | 0.64 |
| Current Smokers | 0.64 (0.28, 1.49) | 0.30 | 0.61 (0.30, 1.26) | 0.18 | 0.67 (0.30, 1.52) | 0.34 |
| More than 1 BP Pills (%) | 1.45 (0.78, 2.71) | 0.24 | 1.46 (0.81, 2.63) | 0.20 | 1.57 (0.85, 2.87) | 0.15 |
| At least 1 BP drug side effect | 0.64 (0.34, 1.20) | 0.16 | 0.68 (0.37, 1.23) | 0.20 | 0.68 (0.37, 1.29) | 0.23 |
| >4 BP drug side effects | 1.03 (0.56, 1.89) | 0.93 | 1.18 (0.68, 2.06) | 0.55 | 0.69 (0.37, 1.29) | 0.25 |
| OSD (above median)b | 0.78 (0.42, 1.43) | 0.42 | 0.80 (0.44, 1.42) | 0.44 | 1.19 (0.66, 2.15) | 0.55 |
| BP drug copayment | 0.61 (0.29, 1.28) | 0.19 | 0.67 (0.36, 1.25) | 0.21 | 0.59 (0.30, 1.15) | 0.12 |
| Medication for other diseases | 1.05 (0.47, 2.36) | 0.90 | 0.70 (0.35, 1.43) | 0.33 | 0.99 (0.43, 2.26) | 0.97 |
| General health (poor/fair) | 1.36 (0.60, 3.07) | 0.46 | 2.06 (1.05, 4.06) | 0.04 | 1.68 (0.74, 3.83) | 0.22 |
| Anxiety score (PGWB) | ||||||
| Tertile 1 (ref) | ||||||
| Tertile 2 | 0.91 (0.50, 1.64) | 0.75 | 0.85 (0.48, 1.53) | 0.60 | 0.87 (0.48, 1.59) | 0.66 |
| Tertile 3 | 2.10 (1.09, 4.03) | 0.03 | 2.04 (1.12, 3.72) | 0.02 | 2.18 (1.11, 4.28) | 0.02 |
| Depression score (BDI-II) | ||||||
| Tertile 1 (ref) | ||||||
| Tertile 2 | 1.62 (0.90, 2.94) | 0.11 | 1.63 (0.95, 2.82) | 0.08 | 1.55 (0.88, 2.75) | 0.13 |
| Tertile 3 | 1.49 (0.79, 2.83) | 0.22 | 1.61 (0.92, 2.82) | 0.10 | 1.41 (0.77, 2.58) | 0.26 |
Abbreviations: BP, blood pressure; BDI-II, Beck Depression Inventory-II; MARS, Medication adherence report scale; OR, odds ratio; OSD, Overall symptom distress score; PGWB, Psychological General Well- Being Index.
Heavy drinkers were participants who had >14 drinks/week for males and >7 drinks/week for females.
Overall symptom distress scores was calculated by multiplying the presence, severity and frequency of each side effect symptom and summing the resulting values for all side effect symptoms. Median score for overall symptom distress score was 7 at visits 1 and 6 at visits 2 and 3, and 5 at visit 4.
Note: False positive adherers are individuals who were identified as non-adherers based on pill count adherence ratio (PCAR<80%) but adherers based on self-reported measurements of adherence.