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. Author manuscript; available in PMC: 2019 Jun 7.
Published in final edited form as: Mol Cell. 2018 Jun 7;70(5):854–867.e9. doi: 10.1016/j.molcel.2018.05.001

Figure 6. RBPs that bind similar motifs often diverge in sequence context preferences.

Figure 6

A. Dispersal of specificities between cluster 1 RBPs. X- and y- axes represent preference for secondary structure over the motif (x) or flanking regions (y). Circle color denotes preference for flanking nucleotide composition. Split semicircles indicate preference for a bipartite motif over a linear motif with the distance between semicircles reflecting preferred spacing of cores.

B. Pairwise distances (1 – Pearson r) of feature-specific R values for pairs of RBPs within a motif cluster (“intra-cluster”) compared to distances between controls (“reps”). *P < 0.05, **P < 0.005, ***P < 0.0005, Wilcoxon rank-sum test.

C. Log2 ratio of Ppaired over U5 occurrences and nucleotides directly upstream and downstream in: RBNS motifs relative to input (top), intronic motifs found eCLIP peaks relative to motifs in control peaks (middle), intronic motifs near exons with increased inclusion upon RBP KD relative to control introns (bottom). *P < 0.05, **P < 0.005, ***P < 0.0005, Wilcoxon rank-sum test.