Fig. 4. Oxy-PAHs inhibit TCDD induced cellular EROD activity. HaCaT cells were exposed to TCDD alone (5 nM) or in combination with 0.1, 1.0 or 10 μM oxy-PAH and effects on CYP1-dependent EROD activity was measured at 6, 12 and 24 h after exposure. 100% is the EROD activity induced by TCDD alone. Data points represent means ± SE, n = 3. #Increased cytotoxicity. *p < 0.05 as compared with TCDD alone by two-way ANOVA.
