Fig. 5. Oxy-PAHs inhibit TCDD induced CYP1 gene expression. HaCaT cells were exposed to TCDD alone (5 nM) or in combination with 0.1, 1.0 or 10 μM oxy-PAH and effects on gene expression of CYP1A1 (left panels) and CYP1B1 (right panels) were determined by qRT-PCR at 6 h after exposure. 100% is the mRNA level induced by TCDD alone. Data points represent means ± SE, n = 3. #Increased cytotoxicity. *p < 0.05 as compared with TCDD alone by two-way ANOVA.
