Fig. 1. Bioinformatics analysis of lncRNA-MALAT1. (A) Co-expression network of lncRNA-MALAT1 and mRNA was constructed with cytoscape software (http://www.cytoscape.org/) based on the correlation analysis between lncRNA-MALAT1 and differentially expressed mRNAs in Cd-induced 35th 16HBE cells as compared to untreated 16HBE cells. (B) GO and signaling pathway analysis of lncRNA-MALAT1. Pathway analysis was predominantly based on the KEGG database, and the mRNAs were annotated and classified according to the GO database.