Fig. 5. Intracellular ROS and mitochondrial membrane potential (MMP), induced by three sizes of silica particles (Si200, Nano-Si60, Nano-Si40), in BEAS-2B cells. Intracellular ROS generation (A, a) and mitochondrial damage (B, b) in BEAS-2B cells treated with silica particles obviously increased in a size- and dose-dependent manner. Data are expressed as mean ± S.D. *p < 0.05 compared with control group, #p < 0.05 compared with Si200 treated group, &p < 0.05 compared with Nano-Si60 treated group.
