Table 1. Summary of the molecular sizes and subcellular localizations of ZIP8.
Protein | Localization | Molecular size | Tissue/cell line | Expression | Ref. |
hZIP8 | Lysosome | 52 kDa | HeLa | Endogenous | 10 |
hZIP8 | PM/cytosol | Membrane (140 kDa)/cytosol (55 kDa) | BEAS-2B/ hLECs | Endogenous | 15 |
hZIP8-DsRed | PM/mitochondria/cytosol | PM, mitochondria (140 kDa)/cytosol (55 kDa) | BEAS-2B | Transient transfection | |
hZIP8 | PM/lysosome | 150 kDa/75 kDa | T cells | Endogenous | 8 |
hZIP8 | PM/cytosol/ER | 80 kDa/49 kDa | Human proximal tubule cells | Endogenous | 40 |
hZIP8 | ND | 80 kDa/49 kDa/43 kDa | Normal proximal and distal tubule cells | Endogenous | |
hZIP8 | PM/cytosol/ER | 80 kDa/49 kDa/43 kDa | Parental UROtsa | Endogenous | |
hZIP8 | PM/cytosol/ER | 49 kDa | Normal urothelial cells | Endogenous | |
hZIP8 | Membrane/cytosol | 140 kDa/55 kDa/>140 kDa (induced) | THP1/A549 /Macrophage | Endogenous | 17 |
mZIP8-HA | PM | 86 kDa/55 kDa | MFF | Retroviral transfection | 76 |
mZIP8-HA | Apical surface | Unknown | MDCK | Transient transfection | 44 |
mZIP8 | PM | Unknown | Kidney | Transgenic | 104 |
mZIP8 | PM | 120 kDa/60 kDa | RBCs | Endogenous | 41 |
rZIP8 | PM/cytosol/endosome | 100 kDa/80 kDa/45 kDa | HEK-293T | Transient transfection | 12 |
rZIP8 | PM/cytosol | 150 kDa/140 kDa/130 kDa | H4IIE cells | Endogenous | |
rZIP8 | PM | 100 kDa/50 kDa | Primary hippocampal neurons | Endogenous | 78 |
rZIP8 | Apical surface /Nucleus | ND | Hair cells in the inner ear | Endogenous | 45 |