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. 2016 Feb 18;5(4):987–1002. doi: 10.1039/c5tx00424a

Table 1. Summary of the molecular sizes and subcellular localizations of ZIP8.

Protein Localization Molecular size Tissue/cell line Expression Ref.
hZIP8 Lysosome 52 kDa HeLa Endogenous 10
hZIP8 PM/cytosol Membrane (140 kDa)/cytosol (55 kDa) BEAS-2B/ hLECs Endogenous 15
hZIP8-DsRed PM/mitochondria/cytosol PM, mitochondria (140 kDa)/cytosol (55 kDa) BEAS-2B Transient transfection
hZIP8 PM/lysosome 150 kDa/75 kDa T cells Endogenous 8
hZIP8 PM/cytosol/ER 80 kDa/49 kDa Human proximal tubule cells Endogenous 40
hZIP8 ND 80 kDa/49 kDa/43 kDa Normal proximal and distal tubule cells Endogenous
hZIP8 PM/cytosol/ER 80 kDa/49 kDa/43 kDa Parental UROtsa Endogenous
hZIP8 PM/cytosol/ER 49 kDa Normal urothelial cells Endogenous
hZIP8 Membrane/cytosol 140 kDa/55 kDa/>140 kDa (induced) THP1/A549 /Macrophage Endogenous 17
mZIP8-HA PM 86 kDa/55 kDa MFF Retroviral transfection 76
mZIP8-HA Apical surface Unknown MDCK Transient transfection 44
mZIP8 PM Unknown Kidney Transgenic 104
mZIP8 PM 120 kDa/60 kDa RBCs Endogenous 41
rZIP8 PM/cytosol/endosome 100 kDa/80 kDa/45 kDa HEK-293T Transient transfection 12
rZIP8 PM/cytosol 150 kDa/140 kDa/130 kDa H4IIE cells Endogenous
rZIP8 PM 100 kDa/50 kDa Primary hippocampal neurons Endogenous 78
rZIP8 Apical surface /Nucleus ND Hair cells in the inner ear Endogenous 45