Table 2. Summary of the association of rs13107325 (SLC39A8 T allele) with various human complex traits.
Traits | Sample size |
Frequency | P-value | Region | Study | Ref. | |
Initial | Replication | ||||||
SBP, DBP, HP | 69 395 | 133 361 | 0.05 | 2.30 × 10–17 | EU | Ehret et al. (2011) | 19 |
DBP | 87 736 | 68 368 | ND | ND | EU | Tragante et al. (2014) | 23 |
BMI, Obesity | 123 865 | 125 931 | 0.07 | 1.50 × 10–13 | EU | Speliotes et al. (2010) | 18 |
BMI | 168 267 | 109 703 | ND | ND | EU | Berndt et al. (2013) | 21 |
HDL-C | 16 056 | 22 128 | 0.08 | 2.1 × 10–3 | EU | Waterworth et al. (2010) | 93 |
HDL-C | 99 900 | — | 0.07 | <7 × 10–11 | EU | Teslovich et al. (2010) | 92 |
HDL-C | 94 595 | 93 982 | 0.08 | 1.10 × 10–15 | EU | Willer et al. (2013) | 94 |
Schizophrenia | 4545 cases; 15 575 controls | — | 0.08 | 2.7 × 10–6 | EU | Carrera et al. (2012) | 20 |
Schizophrenia | 35 476 cases; 46 839 controls | — | 0.08 | 1.54 × 10–12 | EU | Ripke et al. (2014) | 22 |
Stress | 182 | — | ND | ND | EU | Bruenig et al. (2014) | 97 |
Gray matter volume | 1292 | — | >0.07, <0.08 | <10 × 10–4 | EU | Lajous et al. (2015) | 98 |
Mn level in serum | 949 | — | ND | 5.1 × 10–11 | EU | Ng et al. (2015) | 95 |