Table 1. Animal data (males): animals were exposed to 0, 3, or 30 mg per kg bw per d for 7 days.

	HBCD-group	0	3	30	Thyroid effect (P-value)	HBCD effect (P-value)	Interaction (P-value)	Spearman's Rho
Body weight (g)	ET	427 ± 36	428 ± 35	430 ± 27	<0.001	0.828	0.736	–0.045
	HT	165 ± 22	153 ± 45	146 ± 32				–0.272
Liver weight (g)	ET	16.30 ± 1.12	16.14 ± 1.93	16.44 ± 1.68	<0.001	0.867	0.766	0.058
	HT	5.49 ± 0.80	5.12 ± 1.71	4.78 ± 1.11				–0.295
TSH (ng ml–1)	ET	0.38 ± 0.34	1.27 ± 0.92	0.49 ± 0.27	<0.001	0.810	0.409	0.168
	HT	17.01 ± 5.06	14.51 ± 4.31	16.76 ± 4.40				–0.012
Total T4 (μg dl–1)	ET	4.4 ± 0.3	3.9 ± 0.8	4.2 ± 0.5	<0.001	0.189	0.229	–0.306
	HT	<lod	<lod	<lod				0.433
Total T3 (ng ml–1)	ET	230 ± 48	234 ± 41	196 ± 9	<0.001	0.189	0.587	–0.35
	HT	165 ± 12	177 ± 25	161 ± 47				–0.148
Free T3 (pg ml–1)	ET	5.95 ± 0.51	6.30 ± 0.61	5.27 ± 0.87	<0.001	0.044	0.326	–0.341
	HT	1.56 ± 0.31	2.39 ± 0.78	1.80 ± 0.60				0.041
LH (ng ml–1)	ET	0.61 ± 0.15	1.22 ± 0.51	0.88 ± 0.30	0.002	0.021	0.088	0.33
	HT	0.54 ± 0.18	0.62 ± 0.28	0.55 ± 0.13				0.018
FSH (ng ml–1)	ET	3.81 ± 0.43	5.04 ± 0.80	4.00 ± 0.83	0.065	0.039	0.491	0.161
	HT	3.72 ± 1.15	4.16 ± 1.75	2.91 ± 0.83				–0.359
Testosterone (ng ml–1)	ET	2.23 ± 1.93	1.09 ± 0.36	1.24 ± 0.42	0.645	0.751	0.217	–0.308
	HT	0.98 ± 0.65	1.35 ± 1.45	1.64 ± 1.54				0.233
Leptin (ng ml–1)	ET	8 ± 2	7 ± 2	8 ± 2	0.006	0.205	0.134	0.022
	HT	13 ± 4	12 ± 4	8 ± 4				–0.428
Insulin (ng ml–1)	ET	6.02 ± 1.92	5.18 ± 2.69	8.81 ± 3.77	<0.001	0.174	0.035	0.261
	HT	4.38 ± 2.08	2.26 ± 1.48	2.09 ± 0.81				–0.613**
Corticosterone (ng ml–1)	ET	149 ± 71	103 ± 62	222 ± 69	0.027	0.056	0.549	0.35
	HT	183 ± 46	242 ± 113	353 ± 260				0.193
Internal γ-HBCD (mg per kg lw)	ET	<lod	25.5 ± 5.2	81.0 ± 33.1	0.002	<0.001	0.013
	HT	<lod	40.7 ± 8.6	130.0 ± 32.9