Fig. 4. Gene networks built using the MetaCore database and our gene data. These genes were reported having interactions with (A) CAR and its downstream hub genes, (B) HNF4-alpha, (C) ESR1 and (D) HIF1A. These genes were also reported having relationships to tumors. Genes with red or blue circles indicate up-regulated or down-regulated genes compared to control, respectively. Green, red or gray arrows indicate positive/activation, negative/inhibition or unspecified effects, respectively.