Table 2. Top 10 most hyper- and hypohydroxymethylated gene promoters in hepatocellular tumors of PB-treated mice.

[Hyperhydroxymethylated]
Gene symbol	Distance to TSS	Chromosome	Region start	Region end	Probes in region	p-Value	MAT-score a
Mir1982	–479	chr10	80230053	80231447	38	8.83 × 10–6	10.373
Gm9786	228	chr10	80230053	80231447	38	8.83 × 10–6	10.373
Oaz1	268	chr10	80230053	80231447	38	8.83 × 10–6	10.373
LOC100041223	–2138	chrY_random	12131429	12133005	65	8.83 × 10–6	10.228
LOC100039810	–740	chrY_random	12131429	12133005	65	8.83 × 10–6	10.228
LOC100041256	–740	chrY_random	12131429	12133005	65	8.83 × 10–6	10.228
Igfbp5	–320	chr1	72808393	72809533	29	8.83 × 10–6	10.170
C030023E24Rik	–4736	chrX	57444031	57447222	82	8.83 × 10–6	9.465
Cdr1	0	chrX	57444031	57447222	82	8.83 × 10–6	9.465
Trim32	0	chr4	65091192	65092726	40	8.83 × 10–6	9.444

[Hypohydroxymethylated]
Gene symbol	Distance to TSS	Chromosome	Region start	Region end	Probes in region	p-Value	MAT-score a
2210021J22Rik	–2995	chr15	85642459	85645379	81	8.83 × 10–6	–13.554
Hspa1a	–4679	chr17	34584892	34587462	67	8.83 × 10–6	–12.096
Lsm2	–2724	chr17	34584892	34587462	67	8.83 × 10–6	–12.096
Gstt3	–1851	chr10	75226982	75227939	22	8.83 × 10–6	–12.018
Eid3	0	chr10	82296212	82297783	41	8.83 × 10–6	–11.725
Stk40	–5130	chr4	125599936	125601131	34	8.83 × 10–6	–11.623
Lsm10	979	chr4	125599936	125601131	34	8.83 × 10–6	–11.623
Emg1	–1464	chr6	124679262	124682316	79	8.83 × 10–6	–11.309
Phb2	1354	chr6	124679262	124682316	79	8.83 × 10–6	–11.309
BC021614	542	chr19	4057119	4058753	41	8.83 × 10–6	–11.135

^aThe relative methylation level calculated by the MAT (Model based Analysis of Tiling-arrays) algorithm.