Table 6. Top 20 enrichment for expression-changed genes by MetaCore pathways.

Maps	Total	p-Value	FDR a	In data
Cytoskeleton remodeling_TGF, WNT and cytoskeletal remodeling	111	3.04 × 10–11	2.73 × 10–8	47
Immune response_IL-4-induced regulators of cell growth, survival, differentiation and metabolism	63	1.48 × 10–10	6.63 × 10–8	32
Cell cycle_ESR1 regulation of G1/S transition	33	7.70 × 10–9	1.99 × 10–6	20
Blood coagulation_blood coagulation	39	8.88 × 10–9	1.99 × 10–6	22
Immune response_IL-6 signaling pathway via JAK/STAT	72	4.39 × 10–8	7.89 × 10–6	31
Cell cycle_the metaphase checkpoint	36	6.03 × 10–8	9.02 × 10–6	20
IGF family signaling in colorectal cancer	60	1.07 × 10–7	1.25 × 10–5	27
Immune response_oncostatin M signaling via MAPK in human cells	37	1.12 × 10–7	1.25 × 10–5	20
Cytoskeleton remodeling_cytoskeleton remodeling	102	1.48 × 10–7	1.47 × 10–5	38
Oxidative phosphorylation	105	3.52 × 10–7	3.07 × 10–5	38
Protein folding and maturation_POMC processing	30	4.10 × 10–7	3.07 × 10–5	17
Regulation of lipid metabolism_RXR-dependent regulation of lipid metabolism via PPAR, RAR and VDR	30	4.10 × 10–7	3.07 × 10–5	17
Development_WNT signaling pathway. Part 2	53	4.72 × 10–7	3.26 × 10–5	24
Neurophysiological process_dynein–dynactin motor complex in axonal transport in neurons	54	7.21 × 10–7	4.63 × 10–5	24
Cell adhesion_chemokines and adhesion	100	8.26 × 10–7	4.95 × 10–5	36
Immune response_oncostatin M signaling via MAPK in mouse cells	35	1.28 × 10–6	7.20 × 10–5	18
Cell cycle_role of APC in cell cycle regulation	32	1.40 × 10–6	7.41 × 10–5	17
Immune response_alternative complementary pathway	53	2.04 × 10–6	1.02 × 10–4	23
Cell cycle_chromosome condensation in prometaphase	21	2.50 × 10–6	1.18 × 10–4	13
Cytoskeleton remodeling_role of PKA in cytoskeleton reorganisation	40	3.06 × 10–6	1.37 × 10–4	19

^aMultiple testing correction based on FDR (False Discovery Rate).